RCE uses patented light frequency technology to transdermally acquire a composite of cardiac biomarkers.
Our unique skin-derived approach, enhanced with deep learning techniques, analyzes and associates the transdermal derived optical signatures with cardiac conditions in real-time. This AI-coupled transdermal approach enables the potential application of our platform technology in various emergency care settings and remote monitoring applications.
Non-invasive assessment of myocardial injury in only
3 minutes
anytime, anywhere.
Infrared Spectroscopy
Infrared spectroscopy is a widely used and applied characterization technique in the fields of geology, chemistry, and materials research has the ability to probe into a material at the molecular level. Molecular spectroscopy is one of the cornerstones of analytical tools used to study structural and compositional chemistry.
Our team of scientists have transformed the capabilities of this technology by discovering the interaction between mid-infrared (MIR) radiation with matter, and invented the world’s only mid-infrared spectrophotometric sensor configured within a wrist wearable.
Infrasensor™
Infrasensor™ is a non-invasive wrist-worn device intended for the detection of high-grade obstructive Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS).
The device is intended to aid healthcare providers in evaluating symptomatic patients in acute care settings by providing supplemental information for the early identification of high-grade obstructive NSTE-ACS. High-grade obstructive NSTE-ACS includes acute coronary syndromes due to severe obstructive coronary artery disease, including total coronary artery occlusion.
The working principle of the Infrasensor™ is based on molecular infrared spectroscopy that uses an optical configuration called total internal reflection to assess a Transdermal Derived Infrared Spectrophotometric (TDIS) waveform. The detected infrared light waveform is transmitted from the on-device electronics unit to a secure cloud server where it is processed and analyzed to detect physiologic signals associated with high-grade obstructive NSTE-ACS.
Note: Infrasensor is currently an investigational device used for research purposes only. RCE is working closely with clinical and regulatory affairs to validate the safety and effectiveness prior to de novo pre-market clearance.
The future: Infrasensor-home
At RCE, we envision a future where cardiovascular disease can be better managed by patient’s cardiologist from the comfort of their own homes, providing peace of mind without the need for frequent visits to medical centers. To achieve this, we are developing a compact, wearable device that allows patients to continuously monitor their health in real-time. We believe this innovation will significantly enhance the quality of life for heart patients and substantially reduce health risks.
Licensing opportunities are available towards integrating our AI-based sensor technology with current patch/watch based wearables
Clinical Evidence
Clinical Evidence for Acute Care Heart Attack Diagnostics
- Nature Communications
Titus, J., Wu, A.H.B., Biswal, S. et al. Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin. Commun Med 2, 42 (2022).
- European Heart Journal
Shantanu Sengupta, Siddharth Biswal, Jitto Titus, Atandra Burman, Keshav Reddy, Mahesh C Fulwani, Aziz Khan, Niteen Deshpande, Smit Shrivastava, Naveena Yanamala, Partho P Sengupta, A novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction, European Heart Journal - Digital Health, Volume 4, Issue 3, May 2023, Pages 145–154.
- Clinical and Experimental Emergency Medicine
William Franklin Peacock, Karina Melissa Soto-Ruiz, Allan S. Jaffe, Brian R. Tiffany, Simon A. Mahler, Brian W. Patterson, Alan HB Wu, Robert Christenson, A rapid non-invasive wearable device for assessing cardiac troponin, Clin Exp Emerg Med., 2024 September 06
Clinical Evidence for Continuous Monitoring
- Diagnostics
Li K, Morales-Garza M, Cardoso C, Moctezuma-Ramirez A, Burman A, Titus J, Elgalad A, Perin E. Early Changes in Acute Myocardial Infarction in Pigs: Achieving Early Detection with Wearable Devices. Diagnostics (Basel). 2023 Mar 7;13(6):1006. doi: 10.3390/diagnostics13061006. PMID: 36980316; PMCID: PMC10046897.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046897/pdf/diagnostics-13-01006.pdf
Intellectual Property
To date, RCE has been able to secure the following patents:
Secures underlying physics for transdermal biomarker detection, and secures the wavelengths for Troponin and h-FABP
Secures the design elements for the point of care Infrasensor wearable
Patents the calibration techniques for reliable operations of transdermal infrared spectrophotometric wearables, also secures calibrating biomarker concentration levels based on association curves derived from blood comparisons
Patents the trend analysis for continuously acquired transdermal signals.
Tropsensor: A Rapid Non-Invasive Transdermal Solution For Troponin Measurement
- American Heart Association conference - 2022
- Biomarkers and Personalized Medicine in Cardiovascular Disease Symposium - 2023
Exploration of a rapid transdermal wearable in assessment of cardiac injury
- UT Southwestern Medical Center conference ACTS - 2023
Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin
- American Heart Association conference - 2023
STUDY OF PERI-RESUSCITATION TROPONIN AND OUTCOMES (SANTO) PROOF-OF-CONCEPT STUDY
- American College of Cardiology (ACC) Scientific Session - 2024
THE PROMISE OF CONTINUOUS TRANSDERMAL CARDIAC INJURY BIOMARKER MONITORING DURING PCI: FIRST REAL-WORLD EXPERIENCE
- NASA - 2024
NON-INVASIVE PROTEIN MEASUREMENT BY TRANSCUTANEOUS SENSOR
