RCE uses patented light frequency technology to transdermally measure protein levels in the blood.
Our unique skin-derived approach, enhanced with deep learning techniques, analyzes and associates the transdermal optical signatures with cardiac conditions in real-time. This AI-coupled transdermal approach enables the potential application of our platform technology in various emergency care settings and remote monitoring applications.
Non-invasive assessment of myocardial injury in only
3 minutes
anytime, anywhere.
Infrared Spectroscopy
Infrared spectroscopy is a widely used and applied characterization technique in the fields of geology, chemistry, and materials research has the ability to probe into a material at the molecular level. Molecular spectroscopy is one of the cornerstones of analytical tools used to study structural and compositional chemistry.
Our team of scientists have transformed the capabilities of this technology by discovering the interaction between mid-infrared (MIR) radiation with matter, and invented the world’s only mid-infrared spectrophotometric sensor configured within a wrist wearable.
Infrasensor™
Our flagship wearable prototype, Infrasensor™, offers a breakthrough in non-invasive medical technology by eliminating the need for sample specimens. Instead, it operates through transdermal (through the skin) interrogation, making the monitoring process seamless and comfortable for patients.
This innovative approach allows for real-time assessment of critical biomarkers directly through the skin, enabling continuous monitoring over extended periods. With Infrasensor™, healthcare providers can track biomarker fluctuations as they happen, providing valuable insights into a patient's condition and enabling timely, data-driven medical decisions.
The future: Infrasensor-home
At RCE, we envision a future where cardiovascular disease can be better managed by patient’s cardiologist from the comfort of their own homes, providing peace of mind without the need for frequent visits to medical centers. To achieve this, we are developing a compact, wearable device that allows patients to continuously monitor their health in real-time. We believe this innovation will significantly enhance the quality of life for heart patients and substantially reduce health risks.
Licensing opportunities are available towards integrating our AI-based sensor technology with current patch/watch based wearables
Clinical Evidence
Clinical Evidence for Acute Care Heart Attack Diagnostics
- Nature Communications
Titus, J., Wu, A.H.B., Biswal, S. et al. Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin. Commun Med 2, 42 (2022).
- European Heart Journal
Shantanu Sengupta, Siddharth Biswal, Jitto Titus, Atandra Burman, Keshav Reddy, Mahesh C Fulwani, Aziz Khan, Niteen Deshpande, Smit Shrivastava, Naveena Yanamala, Partho P Sengupta, A novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction, European Heart Journal - Digital Health, Volume 4, Issue 3, May 2023, Pages 145–154.
- Clinical and Experimental Emergency Medicine
William Franklin Peacock, Karina Melissa Soto-Ruiz, Allan S. Jaffe, Brian R. Tiffany, Simon A. Mahler, Brian W. Patterson, Alan HB Wu, Robert Christenson, A rapid non-invasive wearable device for assessing cardiac troponin, Clin Exp Emerg Med., 2024 September 06
Clinical Evidence for Continuous Monitoring
- Diagnostics
Li K, Morales-Garza M, Cardoso C, Moctezuma-Ramirez A, Burman A, Titus J, Elgalad A, Perin E. Early Changes in Acute Myocardial Infarction in Pigs: Achieving Early Detection with Wearable Devices. Diagnostics (Basel). 2023 Mar 7;13(6):1006. doi: 10.3390/diagnostics13061006. PMID: 36980316; PMCID: PMC10046897.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046897/pdf/diagnostics-13-01006.pdf
Clinical Evidence for New Biomarker Discovery
- Paper to be published and linked here soon.
Intellectual Property
To date, RCE has been able to secure the following patents:
Secures underlying physics for transdermal biomarker detection, and secures the wavelengths for Troponin and h-FABP
Secures the design elements for the point of care Infrasensor wearable
Patents the calibration techniques for reliable operations of transdermal infrared spectrophotometric wearables, also secures calibrating biomarker concentration levels based on association curves derived from blood comparisons
Tropsensor: A Rapid Non-Invasive Transdermal Solution For Troponin Measurement
- American Heart Association conference - 2022
- Biomarkers and Personalized Medicine in Cardiovascular Disease Symposium - 2023
Exploration of a rapid transdermal wearable in assessment of cardiac injury
- UT Southwestern Medical Center conference ACTS - 2023
Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin
- American Heart Association conference - 2023
STUDY OF PERI-RESUSCITATION TROPONIN AND OUTCOMES (SANTO) PROOF-OF-CONCEPT STUDY
- American College of Cardiology (ACC) Scientific Session - 2024
THE PROMISE OF CONTINUOUS TRANSDERMAL CARDIAC INJURY BIOMARKER MONITORING DURING PCI: FIRST REAL-WORLD EXPERIENCE
- NASA - 2024
NON-INVASIVE PROTEIN MEASUREMENT BY TRANSCUTANEOUS SENSOR
